Steven Kliewer and David Mangelsdorf at the University of Texas Southwestern Medical Center and their team were studying FGF21 when they discovered that mice that can’t make the hormone take twice as long to recover consciousness after receiving an intoxicating dose of ethanol – the form of alcohol in drinks – compared with their FGF21-producing counterparts.Īnalysis of 85 animals reveals which are best at holding their alcohol Variations in FGF21’s genes and its receptor may affect how much alcohol we consume. Previous research suggests that consuming alcohol is the biggest trigger for FGF21’s production in people, with it reducing our appetite for alcohol and protecting our liver from alcohol-induced injury. The livers of both mice and people make the hormone FGF21, which is known to interact with parts of the brain.
When we consume alcohol, our liver produces more of the hormone FGF21, which helps to protect the organ from alcohol-induced injuryĪ hormone that helps drunk mice to sober up could one day treat acute alcohol poisoning in people.
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